Journal: Molecular Therapy Oncolytics
Article Title: Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models
doi: 10.1016/j.omto.2021.01.009
Figure Lengend Snippet: Impact of vanadyl sulfate plus NDV combination therapy in a subcutaneous RM9 mouse model Male C57BL/6 mice were administered syngeneic 1 × 10 5 RM9 prostate cancer cells subcutaneously. Seven days later, mice received phosphate-buffered saline (i.t.), vanadyl sulfate (40 mg/kg; i.t.), NDV (5.0 × 10 7 PFU; i.t.) or vanadyl sulfate intraperitoneally (i.p.) 4 h prior to i.t. administration of NDV. Mice were euthanized when tumors reached 15 mm in any one direction. Significance was determined using log rank (Mantel-Cox) test (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001).
Article Snippet: DF-1 chicken embryo fibroblast cells (ATCC CRL-12203), B16-F10 murine melanoma cells (ATCC CRL-6475), and RM9 murine prostate cancer cells (ATCC CRL-3312) were purchased from ATCC.
Techniques: Saline